South Lincoln County is based around Kemmerer, Wyoming, located at the intersection of U.S. Highway 30 and U.S. Highway 189. Kemmerer boasts a 8,200 foot general aviation airport, a Wyoming State Port of Entry, and a rail spur for the Union Pacific Railroad. South Lincoln County is the only location in the region to offer two rail sidings with capacity of over 1 mile.

A local freight company, Bonneville Transloaders, Inc. (BTI), operates a bulk freight transportation service out of its Kemmerer office, specializing in minerals such as coal, soda ash, and sulfur.

Kemmerer is 137 miles (two hours) from the Salt Lake City International Airport.